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The systemic inflammatory response syndrome is predictive of renal dysfunction in patients with non-paracetamol-induced acute liver failure

热2 qxm123 添加于 2010-5-15 20:36 | 2049 次阅读 | 0 个评论

作者
Leithead JA, Ferguson JW, Bates CM, Davidson JS, Lee A, Bathgate AJ, Hayes PC, Simpson KJ
摘要
BACKGROUND: Although renal dysfunction is a common complication of acute liver failure (ALF) with significant prognostic implications, the pathophysiological mechanisms remain unclear. The current hypothesis suggests that the renal dysfunction may mirror the hepatorenal syndrome of cirrhosis. However, ALF has distinct clinical characteristics and the circulatory derangement may be more comparable with sepsis. OBJECTIVES: To examine the relationship between the systemic inflammatory response syndrome (SIRS) and renal dysfunction in ALF, and to identify additional risk factors for renal dysfunction. METHODS: A single-centre retrospective study of 308 patients with ALF was carried out. Renal dysfunction was defined according to the RIFLE criteria for acute kidney injury. RESULTS: 67% of patients developed renal dysfunction. On univariate analysis, renal dysfunction patients were more likely to be hypothermic (p = 0.010), had a faster heart rate (p<0.001), a higher white cell count (p = 0.001) and a lower PaCO(2) (p = 0.033). 78% of renal dysfunction patients and 53% of non-renal dysfunction patients had SIRS (p<0.001). On multivariate analysis, the risk factors for renal dysfunction were age (p = 0.024), fulfilled Kings College Hospital prognostic criteria (p<0.001), hypotension (p<0.001), paracetamol-induced ALF (p<0.001), infection (p = 0.077) and SIRS (p = 0.017). SIRS remained an independent predictor of renal dysfunction in the subgroup of patients with non-paracetamol-induced ALF (n = 91, p = 0.001). In contrast, in patients with paracetamol-induced ALF (n = 217), no relationship between SIRS and renal dysfunction was demonstrated (p = 0.373). CONCLUSION: SIRS is strongly associated with the development of renal dysfunction in patients with non-paracetamol-induced ALF. It is proposed that the systemic inflammatory cascade plays a key role in its pathogenesis.
详细资料
- 关键词: Adult; Female; Humans; Kidney Failure, Acute/*etiology/mortality; Liver Failure, Acute/*complications/mortality; Male; Multivariate Analysis; Predictive Value of Tests; Prevalence; Prognosis; Retrospective Studies; Risk Factors; Systemic Inflammatory Response Syndrome/*complications/mortality
- 文献种类:期刊
- 期刊名称: Gut
- 期刊缩写: Gut
- 期卷页: 2009年第58卷第3期 443-449页
- 地址: Scottish Liver Transplant Unit, Royal Infirmary of Edinburgh, 51, Little France Crescent, Edinburgh EH16 4SA, UK. jleithea@staffmail.ed.ac.uk
- ISBN: 0017-5749
- 备注:PMID:19001057
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