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Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study

qxm123 添加于 2010-5-15 20:47 | 1936 次阅读 | 0 个评论

作者
Chen J-H, Chuang S-Y, Chen H-J, Yeh W-T, Pan W-H
摘要
OBJECTIVE: The association between hyperuricemia and cardiovascular events has been documented in high-risk groups, but is still undetermined in general populations, especially Chinese. This study assessed the temporal association between serum uric acid level, hyperuricemia, and cardiovascular mortality. METHODS: A prospective cohort study of 41,879 men and 48,514 women ages > or = 35 years was conducted using data from the MJ Health Screening Centers in Taiwan. Mortality from all causes, total cardiovascular disease (CVD), ischemic stroke, congestive heart failure, hypertensive disease, and coronary heart disease were compared according to increasing serum uric acid levels. RESULTS: A total of 1,151 (21.2%) events of 5,427 total deaths were ascribed to CVD (mean followup 8.2 years). Hazard ratios (HRs) for hyperuricemia (serum uric acid level >7 mg/dl) were estimated with Cox regression model after adjusting for age, sex, body mass index, cholesterol, triglycerides, diabetes, hypertension, heavy cigarette smoking, and frequent alcohol consumption. In all patients, HRs were 1.16 (P < 0.001) for all-cause mortality, 1.39 (P < 0.001) for total CVD, and 1.35 (P = 0.02) for ischemic stroke. In subgroup analysis, the HRs for cardiovascular risk remained significant in patients with hypertension (1.44, P < 0.001) and in patients with diabetes (1.64, P < 0.001). In addition, in a low metabolic risk subgroup, the HRs for all-cause mortality and total cardiovascular morbidity were 1.24 (P = 0.02) and 1.48 (P = 0.16), respectively. CONCLUSION: Hyperuricemia was an independent risk factor of mortality from all causes, total CVD, and ischemic stroke in the Taiwanese general population, in high-risk groups, and potentially in low-risk groups.
详细资料
- 关键词: Adult; Cardiovascular Diseases/blood/*mortality; Female; Humans; Hyperuricemia/*complications; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Risk Factors; Stroke/blood/*mortality; Taiwan/epidemiology; Uric Acid/blood
- 文献种类:期刊
- 期刊名称: Arthritis and Rheumatism
- 期刊缩写: Arthritis Rheum
- 期卷页: 2009年第61卷第2期 225-232页
- 地址: China Medical University Hospital, Taichung, and National Taiwan University, Taipei, Taiwan
- ISBN: 0004-3591
- 备注:PMID:19177541
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我国台湾学者对9万多名35岁以上受试者随访8.2年的结果显示，高尿酸血症(血尿酸> 7 mg/dl)与全因死亡、总体心血管疾病死亡、缺血性卒中和充血性心力衰竭危险增加相关(危险分别增加16%、39%、35%和105%)。血尿酸水平每增加1 mg/dl，全因死亡和心血管疾病相关死亡危险分别增加8%和11%。

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