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Regulation of Alternative Splicing by Histone Modifications

热1 阿土狗添加于 2010-6-10 08:38 | 1394 次阅读 | 0 个评论

作者
Luco RF, Pan Q, Tominaga K, Blencowe BJ, Pereira-Smith OM, Misteli T
摘要
Alternative splicing of pre-mRNA is a prominent mechanism to generate protein diversity, yet its regulation is poorly understood. We demonstrated a direct role for histone modifications in alternative splicing. We found distinctive histone modification signatures that correlate with the splicing outcome in a set of human genes, and modulation of histone modifications causes splice site switching. Histone marks affect splicing outcome by influencing the recruitment of splicing regulators via a chromatin-binding protein. These results outline an adaptor system for the reading of histone marks by the pre-mRNA splicing machinery.
详细资料
- 关键词: BINDING; EXON; TRANSCRIPTION; RECOGNITION; ELONGATION; CODE; IIIB; PTB; H3
- 文献种类:期刊
- 期刊名称: SCIENCE
- 期卷页: 2010年第327卷第5968期 996-1000页
- 出版社: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
- 地址: 1. NCI, NIH, Bethesda, MD 20892 USA 2. Univ Toronto, Banting & Best Dept Med Res, Terrence Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1 Canada 3. Univ Texas Hlth Sci Ctr San Antonio, Barshop Inst Longev & Aging Studies, Dept Cellular & Struct Biol, San Antonio, TX 78245 USA
- ISBN: 0036-8075
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