Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats
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ingrid_86 添加于 2009-7-31 22:51
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作 者
Sun Q, Kang Z, Cai J, Liu W, Liu Y, Zhang JH, Denoble PJ, Tao H, Sun X 摘 要
Protective effect of hydrogen (H2) gas on cardiac ischemia-reperfusion (I/R) injury has been demonstrated previously. This study was designed to test the hypothesis that hydrogen-rich saline (saline saturated with molecular hydrogen) which is easy to use induces cardioprotection against ischemia (30 min) and reperfusion (24 h) injury in rats. Adult male Sprague-Dawley rats underwent 30 minute occlusion of the left anterior descending (LAD) coronary artery and 24 hour reperfusion. Intraperitoneal injection of hydrogen-rich saline before reperfusion significantly decreased plasma and myocardium malondialdehyde (MDA) concentration, decreased cardiac cell apoptosis and myocardial 8-hydroxydeoxyguanosine (8-OHdG) in area at risk zonesAAR, suppressed the activity of caspase 3, and reduced infarct size. The heart function parameters including left ventricular systolic pressure (LVSP), left ventricular diastolic pressure (LVDP)+(dP/dt)max and -(dP/dt)max were also significantly improved 24 h after reperfusion. It is concluded that hydrogen-rich saline is a novel, simple, safe and effective method to attenuate myocardial I/R injury.-
详细资料
- 文献种类:期刊
- 期刊名称: Experimental Biology and Medicine (Maywood, N.J.)
- 期刊缩写: Exp Biol Med (Maywood)
- 期卷页: 2009年
- 地址: Second Military Medical University
- ISBN: 1535-3702
- 备注:PMID:19596825
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