新科学想法 › 文献管理 › 浏览文献

Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties

kekechong 添加于 2010-6-24 11:00 | 937 次阅读 | 0 个评论

作者
Garrido C, Brunet M, Didelot C, Zermati Y, Schmitt E, Kroemer G
摘要
Heat shock proteins (HSP) HSP27 and HSP70 are expressed in response to a wide variety of physiological and environmental insults including anticancer chemotherapy, thus allowing the cell to survive to lethal conditions. Several mechanisms account for the cytoprotective effect of HSP27 and HSP70. (1) Both proteins are powerful chaperones. (2) They both inhibit key effectors of the apoptotic machinery at the pre and post-mitochondrial level. (3) They participate in the proteasome-mediated degradation of proteins under stress conditions, thereby contributing to the so called "protein triage". In cancer cells, the expression of HSP27 and/or HSP70 is abnormally high, and both HSP27 and HSP70 may participate in oncogenesis and in resistance to chemotherapy. In rodent models, HSP27 or HSP70 over-expression increases tumor growth and metastatic potential. The depletion or inhibition of HSP27 and HS70 frequently reduces the size of the tumors and even can cause their complete involution (for HSP70). Therefore, the inhibition of HSP70 and HSP27 has become a novel strategy of cancer therapy.
详细资料
- 关键词: Animals; Antineoplastic Agents/pharmacology; Apoptosis/*physiology; Cytoprotection; HSP70 Heat-Shock Proteins/antagonists & inhibitors/*metabolism; Heat-Shock Proteins/antagonists & inhibitors/*metabolism; Humans; Models, Biological; Neoplasms/*metabolism/therapy; Proteasome Endopeptidase Complex/metabolism
- 文献种类:期刊
- 期刊名称: Cell Cycle (Georgetown, Tex.)
- 期刊缩写: Cell Cycle
- 期卷页: 2006年第5卷第22期 2592-2601页
- 地址: INSERM U-517, Faculty of Medicine and Pharmacy, Universite de Dijon, Dijon, France. cgarrido@u-bourgogne.fr
- ISBN: 1551-4005
- 备注:PMID:17106261
相关链接 URL