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Signal integration by JNK and p38 MAPK pathways in cancer development

kekechong 添加于 2010-6-24 11:05 | 1033 次阅读 | 0 个评论

作者
Wagner EF, Nebreda AR
摘要
Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family members function in a cell context-specific and cell type-specific manner to integrate signals that affect proliferation, differentiation, survival and migration. Consistent with the importance of these events in tumorigenesis, JNK and p38 MAPK signalling is associated with cancers in humans and mice. Studies in mouse models have been essential to better understand how these MAPKs control cancer development, and these models are expected to provide new strategies for the design of improved therapeutic approaches. In this Review we highlight the recent progress made in defining the functions of the JNK and p38 MAPK pathways in different cancers.
详细资料
- 关键词: Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Humans; JNK Mitogen-Activated Protein Kinases/*physiology; MAP Kinase Signaling System/*physiology; Mice; Neoplasms/*etiology/*pathology/therapy; Receptor Cross-Talk; p38 Mitogen-Activated Protein Kinases/*physiology
- 文献种类:期刊
- 期刊名称: Nature Reviews. Cancer
- 期刊缩写: Nat Rev Cancer
- 期卷页: 2009年第9卷第8期 537-549页
- 地址: Centro Nacional de Investigaciones Oncologicas, C/Melchor Fernandez Almagro 3, Madrid 28029, Spain. ewagner@cnio.es
- ISBN: 1474-175X
- 备注:PMID:19629069
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