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Progress in the unraveling of the endoplasmic reticulum stress/autophagy pathway and cancer: implications for future therapeutic approaches

kekechong 添加于 2010-6-24 15:23 | 970 次阅读 | 0 个评论

作者
Schleicher SM, Moretti L, Varki V, Lu B
摘要
Given the inherent resistance to apoptosis that characterizes cancer, the targeting of alternative pathways is an attractive strategy to improve anti-tumor therapy. Endoplasmic reticulum (ER) stress, which is basally activated in many cancers, and the subsequent activation of autophagy represent novel cancer treatment targets. While these associated pathways are often protective and promote cell survival, when excessive, ER stress results in autophagic cell death. Therefore, depending on the circumstances, either inhibition or activation of ER stress and autophagy can improve cancer therapy. This review provides an update on how ER stress relates to autophagy, and how these associated pathways can serve dual functions to promote survival or cell death in cancer. Furthermore, it lays out a spectrum of potential pharmacological agents and combinatorial approaches that target these pathways to enhance tumor cell kill.
详细资料
- 文献种类:期刊
- 期刊名称: Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
- 期刊缩写: Drug Resist Updat
- 期卷页: 2010年第13卷第3期 79-86页
- 地址: Department of Radiation Oncology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, School of Medicine, Nashville, TN, USA
- ISBN: 1368-7646
- 备注:PMID:20471904
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