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有读书笔记有附件Rice SUVH Histone Methyltransferase Genes Display Specific Functions in Chromatin Modification and Retrotransposon Repression

3 yonghao616 添加于 2010-6-26 19:10 | 2223 次阅读 | 3 个评论
  •  作 者

    Qin F-J, Sun Q-W, Huang L-M, Chen X-S, Zhou D-X
  •  摘 要

    Histone lysine methylation plays an important role in heterochromatin formation and reprogramming of gene expression. SET-domain-containing proteins are shown to have histone lysine methyltransferase activities. A large number of SET-domain genes are identified in plant genomes. The function of most SET-domain genes is not known. In this work, we studied the 12 rice (Oryza sativa) homologs of Su(var)3–9, the histone H3 lysine 9 (H3K9) methyltransferase identified in Drosophila. Several rice SUVHs (i.e. SDG714, SDG727, and SDG710) were found to have an antagonistic function to the histone H3K9 demethylase JMJ706, as down-regulation of these genes could partially complement the jmj706 phenotype and reduced histone H3K9 methylation. Down-regulation of a rice Su(var)3–9 homolog (SUVH), namely SDG728, decreased H3K9 methylation and altered seed morphology. Overexpression of the gene increased H3K9 methylation. SDG728 and other SUVH genes were found to be involved in the repression of retrotransposons such as Tos17 and a Ty1-copia element. Analysis of histone methylation suggested that SDG728-mediated H3K9 methylation may play an important role in retrotransposon repression.
  •  详细资料

    • 文献种类:期刊
    • 期刊名称: Molecular Plant
    • 期刊缩写: Molecular Plant
    • ISBN: 1674-2052
  • 相关链接 DOI URL 

  •  附 件

    PDF附件Rice SUVH Histone Methyltransferase Genes Display Specific Functions in Chromatin Modification and Retrotransposon Repression 
  •  yonghao616 的文献笔记  订阅

    水稻SUVH类组蛋白甲基转移酶的功能研究

    周道秀教授的最新研究进展。他们对与果蝇Su(var)3–9(H3K9甲基化酶)同源的水稻中的SUVH(Su(var)3–9 homolog)类酶进行了功能研究,发现有几个酶和H3K9组蛋白去甲基化酶JMJ706的功能是相拮抗的;其中一个SUVH基因SDG728的低表达可以降低H3K9甲基化的水平,并且可以改变种子的形态;该基因的高表达可以增加H3K9甲基化的水平;另外发现有几个SUVH具有抑制一些转座子发生转座的功能。

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