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Pharmacological strategies against cold ischemia reperfusion injury

ingrid_86 添加于 2010-6-26 21:36 | 1770 次阅读 | 0 个评论

作者
Zaouali MA, Ben Abdennebi H, Padrissa-Altes S, Mahfoudh-Boussaid A, Rosello-Catafau J
摘要
IMPORTANCE OF THE FIELD: Good organ preservation is a determinant of graft outcome after revascularization. The necessity of increasing the quality of organ preservation, as well as of extending cold storage time, has made it necessary to consider the use of pharmacological additives. AREAS COVERED IN THIS REVIEW: The complex physiopathology of cold-ischemia-reperfusion (I/R) injury--and in particular cell death, mitochondrial injury and endoplasmic reticulum stress--are reviewed. Basic principles of the formulation of the different preservation solutions are discussed. WHAT THE READER WILL GAIN: Current strategies and new trends in static organ preservation using additives such as trimetazidine, polyethylene glycols, melatonin, trophic factors and endothelin antagonists in solution are presented and discussed. The benefits and mechanisms responsible for enhancing organ protection against I/R injury are also discussed. Graft preservation was substantially improved when additives were added to the preservation solutions. TAKE HOME MESSAGE: Enrichment of preservation solutions by additives is clinically useful only for short periods. For longer periods of cold ischemia, the use of such additives becomes insufficient because graft function deteriorates as a result of ischemia. In such conditions, the preservation strategy should be changed by the use of machine perfusion in normothermic conditions.
详细资料
- 关键词: *Cold Ischemia; Cold Temperature; Humans; Intercellular Signaling Peptides and Proteins/pharmacology; Melatonin/pharmacology; Organ Preservation/*methods; Organ Preservation Solutions/*pharmacology; Perfusion; Polyethylene Glycols/pharmacology; Receptors, Endothelin/antagonists & inhibitors; Reperfusion Injury/drug therapy/physiopathology/*prevention & control; Tissue and Organ Procurement/*methods; Trimetazidine/pharmacology
- 文献种类:期刊
- 期刊名称: Expert Opinion on Pharmacotherapy
- 期刊缩写: Expert Opin Pharmacother
- 期卷页: 2010年第11卷第4期 537-555页
- 地址: Experimental Hepatic Ischemia-Reperfusion Unit, Institut d'Investigacions Biomediques de Barcelona, CSIC-IDIBAPS, C/Rossello 161, 7th floor, E-08036-Barcelona, Spain. jrcbam@iibb.csic.es
- ISBN: 1465-6566
- 备注:PMID:20163266
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