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Echocardiographic examination in rats and mice

ingrid_86 添加于 2010-6-29 21:48 | 1845 次阅读 | 0 个评论

作者
Liu J, Rigel DF
摘要
Rats and mice are the predominant experimental species in cardiovascular research due to the widespread availability of genetic and transgenic rodent models of heart disease. Phenotyping of these models requires reliable and reproducible methods to noninvasively and serially assess cardiovascular structure and function. However, the small size of rodents has presented a challenge. Many of these challenges have been overcome in recent years due to significant technological advances in echocardiographic capabilities. For example, improved spatial resolution and increased frame rates have allowed more precise and accurate quantification of diminutive structures, myocardial function, and blood flow in mice. Consequently, transthoracic echocardiography (TTE) has emerged as a popular and powerful tool for cardiac phenotypic characterization in rodents. This chapter will focus on the use of TTE in rodents for evaluating (1) left ventricular (LV) chamber dimensions and wall thickness, (2) LV mass, (3) global LV systolic and diastolic function, (4) regional LV systolic function by newly developed tissue Doppler imaging (TDI), and (5) hemodynamic parameters. Reliability of these measurements depends on various factors such as the skill and experience of the sonographer and the image analyzer, the type, depth, and duration of anesthesia, and animal characteristics. These topics will also be discussed.
详细资料
- 关键词: Anesthesia/methods/veterinary; Animals; Cardiovascular Physiological Processes; Echocardiography/*methods/veterinary; Handling (Psychology); Hemodynamics/physiology; Image Processing, Computer-Assisted/methods; Mice; Rats
- 文献种类:期刊
- 期刊名称: Methods in Molecular Biology (Clifton, N.J.)
- 期刊缩写: Methods Mol Biol
- 期卷页: 2009年第573卷 139-155页
- 地址: Novartis Institutes for BioMedical Research and Novartis Pharmaceutical Corporation, East Hanover, NJ, USA
- ISBN: 1064-3745
- 备注:PMID:19763926
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