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有读书笔记有附件Histone acetylation in heterochromatin assembly

yonghao616 添加于 2010-7-6 14:58 | 1742 次阅读 | 0 个评论
  •  作 者

    Kim JH, Workman JL
  •  摘 要

    Histone acetylation is generally considered a mark involved in activating gene expression by making chromatin structures less compact. In the April 1, 2010, issue of Genes & Development, Xhemalce and Kouzarides (pp. 647–652) demonstrate that the acetylation of histone H3 at Lys 4 (H3K4) plays a role in the formation of repressive heterochromatin in Schizosaccharomyces pombe. H3K4 acetylation mediates a switch of chromodomain proteins associated with methylated H3K9 during heterochromatin assembly.
  •  详细资料

    • 文献种类:期刊
    • 期刊名称: Genes & Development
    • 期刊缩写: Genes & Development
    • 期卷页: 2010  24 8 738-740
    • ISBN: 0890-9369
  • 相关链接 DOI URL 

  •  附 件

    PDF附件Histone acetylation in heterochromatin assembly  PDF附件Histone acetylation in heterochromatin assembly 
  •  yonghao616 的文献笔记  订阅

    H3K4乙酰化介导了异染色质的形成

    异染色质形成过程中,Chromodomain蛋白结合甲基化的H3K9是个重要的过程。发现两类Chromodomain蛋白,一类是可以结合有转录活性的异染色质的,如Chp1和Clr4;另一类是和HP1同源的蛋白,结合在沉默的异染色质上,如Chp2和Swi6。研究发现H3K4ac在介导以上两种状态的转换过程中起到了重要的作用。

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