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FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link Repair

butterfly09 添加于 2010-8-17 13:29 | 949 次阅读 | 0 个评论
  •  作 者

    Liu T, Ghosal G, Yuan J, Chen J, Huang J
  •  摘 要

    Fanconi anemia (FA) is caused by mutations in 13 Fanc genes and renders cells hypersensitive to DNA interstrand cross-linking (ICL) agents. A central event in the FA pathway is mono-ubiquitylation of the FANCI-FANCD2 (ID) protein complex. Here, we characterize a previously unrecognized nuclease, Fanconi anemia–associated nuclease 1 (FAN1), that promotes ICL repair in a manner strictly dependent on its ability to accumulate at or near sites of DNA damage and that relies on mono-ubiquitylation of the ID complex. Thus, the mono-ubiquitylated ID complex recruits the downstream repair protein FAN1 and facilitates the repair of DNA interstrand cross-links.
  •  详细资料

    • 文献种类:期刊
    • 期刊名称: Science
    • 期刊缩写: Science
    • 期卷页: 2010  329 5992 693-696
    • ISBN: 0036-8075
  •  标 签

  • 相关链接 DOI URL 

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