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Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon

tideyang606 添加于 2010-10-27 00:13 | 1761 次阅读 | 0 个评论

作者
Cervantes-Barragan L, Zust R, Weber F, Spiegel M, Lang KS, Akira S, Thiel V, Ludewig B
摘要
This study demonstrates a unique and crucial role of plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-α production following encounter with this cytopathic RNA virus. Furthermore, the particular type I IFN response pattern was not restricted to the murine coronavirus, but was also found in infection with the highly cytopathic human severe acute respiratory syndrome (SARS) coronavirus. Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections. (Blood. 2007;109:1131-1137)
详细资料
- 文献种类:期刊
- 期刊名称: Blood
- 期刊缩写: Blood
- 期卷页: 2006年第109卷第3期 1131-1137页
- ISBN: 0006-4971
标签

DC virus infection
相关链接 DOI URL