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Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein-

热1 lufuhao 添加于 2010-11-11 11:00 | 2392 次阅读 | 0 个评论

作者
Kraman M, Bambrough PJ, Arnold JN, Roberts EW, Magiera L, Jones JO, Gopinathan A, Tuveson DA, Fearon DT
摘要
The stromal microenvironment of tumors, which is a mixture of hematopoietic and mesenchymal cells, suppresses immune control of tumor growth. A stromal cell type that was first identified in human cancers expresses fibroblast activation protein–{alpha} (FAP). We created a transgenic mouse in which FAP-expressing cells can be ablated. Depletion of FAP-expressing cells, which made up only 2% of all tumor cells in established Lewis lung carcinomas, caused rapid hypoxic necrosis of both cancer and stromal cells in immunogenic tumors by a process involving interferon-{gamma} and tumor necrosis factor–{alpha}. Depleting FAP-expressing cells in a subcutaneous model of pancreatic ductal adenocarcinoma also permitted immunological control of growth. Therefore, FAP-expressing cells are a nonredundant, immune-suppressive component of the tumor microenvironment.
详细资料
- 文献种类:期刊
- 期刊名称: Science
- 期刊缩写: Science
- 期卷页: 2010年第330卷第6005期 827-830页
- ISBN: 0036-8075
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