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Next-generation DNA sequencing

biocq 添加于 2010-11-12 14:20 | 1948 次阅读 | 0 个评论

作者
Shendure J, Ji H
摘要
DNA sequence represents a single format onto which a broad range of biological phenomena can be projected for highthroughput data collection. Over the past three years, massively parallel DNA sequencing platforms have become widely available, reducing the cost of DNA sequencing by over two orders of magnitude, and democratizing the field by putting the sequencing capacity of a major genome center in the hands of individual investigators. These new technologies are rapidly evolving, and near-term challenges include the development of robust protocols for generating sequencing libraries, building effective new approaches to data-analysis, and often a rethinking of experimental design. Next-generation DNA sequencing has the potential to dramatically accelerate biological and biomedical research, by enabling the comprehensive analysis of genomes, transcriptomes and interactomes to become inexpensive, routine and widespread, rather than requiring significant production-scale efforts.
详细资料
- 文献种类:期刊
- 期刊名称: Nature Biotechnology
- 期刊缩写: Nat Biotechnol
- 期卷页: 2008年第26卷第10期 1135-1145页
- ISBN: 1087-0156
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综述测序
相关链接 DOI URL
附件
Next-generation DNA sequencing

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