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Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities

聚焦生物添加于 2010-11-29 06:29 | 1827 次阅读 | 0 个评论

作者
Allard P, Colaiacovo MP
摘要
Bisphenol A (BPA) is a highly prevalent constituent of plastics that has been associated with diabetes, cardiovascular disease, and an increased risk of miscarriages in humans. In mice, BPA exposure disrupts the process of meiosis; however, analysis of the affected molecular pathways is lagging and has been particularly challenging. Here we show that exposure of the nematode Caenorhabditis elegans to BPA, at internal concentrations consistent with mammalian models, causes increased sterility and embryonic lethality. BPA exposure results in impaired chromosome synapsis and disruption of meiotic double-strand break repair (DSBR) progression. BPA carries an anti-estrogenic activity in the germline and results in germline-specific down-regulation of DSBR genes, thereby impairing maintenance of genomic integrity during meiosis. C. elegans therefore constitutes a model of remarkable relevance to mammals with which to assess how our chemical landscape affects germ cells and meiosis.
详细资料
- 文献种类:期刊
- 期刊名称: Proceedings of the National Academy of Sciences of the United States of America
- 期刊缩写: Proc Natl Acad Sci U S A
- 期卷页: 2010年第107卷第47期 20405-20410页
- 地址: Department of Genetics, Harvard Medical School, Boston, MA 02115
- ISBN: 0027-8424
- 备注:PMID:21059909
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双酚A导致线虫不育

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