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有读书笔记Motor and cognitive outcomes through three years of age in children exposed to prenatal methamphetamine

shenww 添加于 2011-1-25 13:46 | 2704 次阅读 | 0 个评论

  •  作 者

    Smith LM, LaGasse LL, Derauf C, Newman E, Shah R, Haning W, Arria A, Huestis M, Strauss A, Della Grotta S

  •  摘 要

    Background Methamphetamine (MA) use among pregnant women is an increasing problem in the United States. The impact of prenatal MA exposure on development in childhood is unknown. Objective To examine the effects of prenatal MA exposure on motor and cognitive development in children at 1, 2, and 3 years of age. Design/methods IDEAL enrolled 412 mother–infant pairs at four sites (Tulsa OK, Des Moines IA, Los Angeles CA, and Honolulu HI). MA subjects (n = 204) were identified by self report or GC/MS confirmation of amphetamine and metabolites in infant meconium. Comparison subjects (n = 208) were matched (race, birth weight, maternal education, and type of insurance), denied amphetamine use, and had a negative meconium screen. Both groups included prenatal alcohol, tobacco and marijuana use, but excluded use of opiates, lysergic acid diethylamide, phencyclidine or cocaine only. The Peabody Developmental Motor Scales (PDMS-2) were administered to the infants at the 1 and 3 year visits. This analysis includes a subsample (n = 350) of the IDEAL study with completed 1 and/or 3 year visits (n = 330 and 281, respectively). At each annual visit we also conducted the Bayley Scales of Infant Development (BSID-II) as a general evaluation of mental and motor development. The BSID-II analysis includes a subsample (n = 356) of the IDEAL study with completed 1, 2, and/or 3 year visits (n = 331, 288, and 278 respectively). GLM analysis conducted on the PDMS-2 and BSID-II examined the effects of MA exposure and heavy MA exposure (≥ 3 days of use/week), with and without covariates. Longitudinal analyses were used to examine the effects of MA exposure on changes in motor and cognitive performance over time. Results Heavy MA exposure was associated with significantly lower grasping scores than some and no use at 1 year (P = 0.018). In longitudinal analysis, lower grasping scores associated with any MA exposure and heavy exposure persisted to 3 years. There were no effects of MA exposure, including heavy exposure, on the Bayley Mental Development Index (MDI) or Psychomotor Development Index (PDI) at any or across age. Conclusions There were no differences in cognition as assessed by the BSID-II between the groups. There was a subtle MA exposure effect on fine motor performance at 1 year with the poorest performance observed in the most heavily exposed children. By 3 years, no differences in fine motor performance were observed. These findings suggest MA exposure has modest motor effects at 1 year that are mostly resolved by 3 years. Keywords: Prenatal exposure; Neurodevelopment; Bayley; Peabody

  •  详细资料

    • 文献种类:期刊
    • 期刊名称: Neurotoxicology and Teratology
    • 期刊缩写: Neurotoxicology and Teratology
    • 期卷页: 2011年  第33卷 第1期 176-184页
    • ISBN: 0892-0362

  •  标 签

    urodevelopment  meth  prenatal exposure 

  • 相关链接 DOI URL 

  •  shenww 的文献笔记  订阅

    摘要
    grasping scores 降低（1岁）
    Bayley Mental Development Index （对智力和运动发育的大体评估）不变
    Psychomotor Development Index 不变
    结论为胎儿期接受meth对认知无明显影响，在一岁左右对精细运动有轻微影响，但在3岁左右已无差异。
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