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Methamphetamine-sensitized mice are accompanied by memory impairment and reduction of NMDA receptor ligand binding in the prefrontal cortex and hippocampus

shenww 添加于 2011-1-25 13:55 | 3041 次阅读 | 0 个评论

作者
Lee K-W, Kim H-C, Lee S-Y, Jang C-G
摘要
Abstract The aim of the present study was to investigate a causal relationship between low-dose methamphetamine-induced (METH - 2mg/kg i.p. once every other day for seven days) behavioral sensitization and memory function. We first investigated the spatial working memory (short-term memory) and long-term memory in mice behaviorally sensitized by repeated METH treatments. We also assessed changes in NMDA receptor binding in METH-treated mice. Acute METH administration induces hyperlocomotion but not induce memory impairment of changes in NMDA receptor binding. However, repeated METH treatment in mice produced behavioral sensitization and showed memory impairment and a decrease in NMDA receptor binding in the prefrontal cortex, as well as in the CA1, CA2, and CA3 regions of the hippocampus. These results suggest that repeated METH-induced behavioral sensitization may be accompanied by memory impairment, characterized by decreased NMDA receptor binding in the prefrontal cortex and hippocampus. Our study shows clearly that repeated but not acute low dose METH treatment induces memory impairment in mice and the possible mechanism involves reduction of NMDA receptor binding in specific brain regions associated with learning and memory. To whom correspondence should be addressed: Choon-Gon Jang, Ph.D., Associate Professor, Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, 300 Cheoncheon-dong, Jangan-gu, Suwon, 440-746, Republic of Korea, Tel: 82-31-290-7780, Fax: 82-31-292-8800
详细资料
- 文献种类:期刊
- 期刊名称: Neuroscience
- 期刊缩写: Neuroscience
- 期卷页: 2011年
- ISBN: 0306-4522
标签

meth memory NMDA hippocampus rat prefrontal cortex
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摘要

repeated METH-induced behavioral sensitization may be accompanied by memory impairment, characterized by decreased NMDA receptor binding in the prefrontal cortex and hippocampus.

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