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Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses

txq01001 添加于 2011-1-31 10:07 | 1903 次阅读 | 0 个评论

作者
Yvan-Charvet L, Wang N, Tall AR
摘要
Atherosclerosis has been characterized as a chronic inflammatory response to cholesterol deposition in arteries, but the mechanisms linking cholesterol accumulation in macrophage foam cells to inflammation are poorly understood. Macrophage cholesterol efflux occurs at all stages of atherosclerosis and protects cells from free cholesterol and oxysterol-induced toxicity. The ATP-binding cassette transporters ABCA1 and ABCG1 are responsible for the major part of macrophage cholesterol efflux to serum or HDL in macrophage foam cells, but other less efficient pathways such as passive efflux are also involved. Recent studies have shown that the sterol efflux activities of ABCA1 and ABCG1 modulate macrophage expression of inflammatory cytokines and chemokines as well as lymphocyte proliferative responses. In macrophages, transporter deficiency causes increased signaling via various Toll-like receptors including TLR4. These studies have shown that the traditional roles of HDL and ABC transporters in cholesterol efflux and reverse cholesterol transport are mechanistically linked to antiinflammatory and immunosuppressive functions of HDL. The underlying mechanisms may involve modulation of sterol levels and lipid organization in cell membranes.
详细资料
- 文献种类:期刊
- 期刊名称: Arteriosclerosis, Thrombosis, and Vascular Biology
- 期刊缩写: Arterioscler Thromb Vasc Biol
- 期卷页: 2010年第30卷第2期 139-143页
- 地址: Division of Molecular Medicine, Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA. ly2159@columbia.edu
- ISBN: 1079-5642
- 备注:PMID:19797709
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附件
Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune resp