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Transcriptional diversification and functional conservation between DELLA proteins in Arabidopsis

cflikunlun 添加于 2011-4-20 09:19 | 1653 次阅读 | 0 个评论

作者
Gallego-Bartolome J, Minguet EG, Marin JA, Prat S, Blazquez MA, Alabadi D
摘要
Plasticity and robustness of signaling pathways partly rely on genetic redundancy, although the precise mechanism that provides functional specificity to the different redundant elements in a given process is often unknown. In Arabidopsis, functional redundancy in gibberellin signaling has been largely attributed to the presence of five members of the DELLA family of transcriptional regulators. Here, we demonstrate that two evolutionarily and functionally divergent DELLA proteins, RGL2 and RGA, can perform exchangeable functions when they are expressed under control of the reciprocal promoter. Furthermore, both DELLA proteins display equivalent abilities to interact with PIF4 and with other bHLH transcription factors with a reported role in the control of cell growth and seed germination. Therefore, we propose that functional diversification of Arabidopsis DELLA proteins has largely relied on changes in their gene expression patterns rather than on their ability to interact with different regulatory partners, model also supported by a clustering analysis of DELLA transcript profiles over a range of organs and growth conditions that revealed specific patterns of expression for each of these genes.
详细资料
- 文献种类:期刊
- 期刊名称: Molecular Biology and Evolution
- 期刊缩写: Mol Biol Evol
- 期卷页: 2010年第27卷第6期 1247-1256页
- 地址: Instituto de Biologia Molecular y Celular de Plantas (UPV-Consejo Superior de Investigaciones Cientificas), Universidad Politecnica de Valencia, Valencia, Spain
- ISBN: 0737-4038
- 备注:PMID:20093430
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附件
Transcriptional diversification and functional conservation between DELLA protei
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