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The glomerulus--a view from the outside--the podocyte

kidneyle 添加于 2011-4-25 11:11 | 943 次阅读 | 0 个评论

作者
Cheng H, Harris RC
摘要
In the past decade, podocyte research has been greatly aided by the development of powerful new molecular, cellular and animal tools, leading to elucidation of an increasing number of proteins involved in podocyte function and identification of mutated genes in hereditary glomerulopathies. Accumulating evidence indicates that podocyte disorders may not only underlie these hereditary glomerulopathies but also play crucial role in a broad spectrum of acquired glomerular diseases. Genetic susceptibility, environmental influence and systemic responses are all involved in the mediation of the pathogenesis of podocytopathies. Injured podocytes may predisopose to further injury of other podocytes and other adjacent/distant renal cells in a vicious cycle, leading to inexorable progression of glomerular injury. The classic view is that podocytes have a limited ability to proliferate in the normal mature kidney. However, recent research in rodents has provided suggestive evidence for podocyte regeneration resulting from differentiation of progenitor cells within Bowman's capsule.
详细资料
- 文献种类:期刊
- 期刊名称: The International Journal of Biochemistry & Cell Biology
- 期刊缩写: Int J Biochem Cell Biol
- 期卷页: 2010年第42卷第9期 1380-1387页
- 地址: Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2372, USA. huifang.cheng@vanderbilt.edu
- ISBN: 1357-2725
- 备注:PMID:20542138
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