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Immune escape from HIV-specific antibody-dependent cellular cytotoxicity (ADCC) pressure

俞艳添加于 2011-5-9 20:20 | 1710 次阅读 | 0 个评论

作者
Chung AW, Isitman G, Navis M, Kramski M, Center RJ, Kent SJ, Stratov I
摘要
Effective immunity to HIV is poorly understood. In particular, a role for antibody-dependent cellular cytotoxicity (ADCC)in controlling HIV is controversial. We hypothesized that significant pressure from HIV-specific ADCC would result in immune-escapevariants. A series of ADCC epitopes in HIV-infected subjects to specific consensus strain HIV peptides were mapped using aflow cytometric assay for natural killer cell activation. We then compared the ADCC responses to the same peptide epitopederived from the concurrent HIV sequence(s) expressed in circulating virus. In 9 of 13 epitopes studied, ADCC antibodies wereunable to recognize the concurrent HIV sequence. Our studies suggest ADCC responses apply significant immune pressure on thevirus. This result has implications for the induction of ADCC responses by HIV vaccines.
详细资料
- 文献种类:期刊
- 期刊名称: Proceedings of the National Academy of Sciences
- 期刊缩写: Proceedings of the National Academy of Sciences
- 期卷页: 2011年第108卷第18期 7505-7510页
- ISBN: 0027-8424
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