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有读书笔记Fear of dying and inflammation following acute coronary syndrome

唐唐 添加于 2011-6-8 03:16 | 3513 次阅读 | 0 个评论

  •  作 者

    Steptoe A, Molloy GJ, Messerli-Burgy N, Wikman A, Randall G, Perkins-Porras L, Kaski JC

  •  摘 要

    Aims Many patients are afraid of dying during acute coronary syndrome (ACS), but the origins and biological correlates of these emotional responses are poorly understood. This study evaluated the prevalence of fear of dying, associations with inflammatory responses during ACS, and later heart rate variability (HRV) and cortisol secretion. Methods and results Two hundred and eight patients admitted with clinically verified ACS rated their fear of dying on interview in hospital. Plasma tumour necrosis factor (TNF)α was recorded on admission, and HRV and salivary cortisol were assessed 3 weeks later. Intense distress and fear of dying was experienced by 21.7%, with moderate levels in 66.1% patients. Fear of dying was more common in younger, lower socioeconomic status, and unmarried patients. It was positively associated with plasma TNFα on admission after controlling for sociodemographic factors, clinical risk, and pain intensity (adjusted odds = 4.67, 95% C.I. 1.66–12.65). TNFα was associated with reduced HRV 3 weeks later, adjusting for clinical and sociodemographic factors and medication (P = 0.019), while fear of dying was associated with reduced cortisol output (P = 0.004). Conclusions Intense distress and fear of dying and heightened inflammation may be related manifestations of an acute biobehavioural response to severe cardiac injury, and have imp

  •  详细资料

    • 文献种类:期刊
    • 期刊名称: European Heart Journal
    • 期刊缩写: European Heart Journal
    • ISBN: 0195-668X

  •  所属群组

    分享医学综合  

  • 相关链接 DOI URL 

  •  唐唐 的文献笔记  订阅

    研究显示害怕情绪会加重心脏病风险
    英国一项最新研究说，如果人们在有心脏病症状时表现出严重的害怕情绪，可能会使血液中一些易引起发炎的化学物质含量升高，从而加重心脏病风险。
     
    英国伦敦大学学院的研究人员在新一期《欧洲心脏期刊》（European Heart Journal）上报告说，调查分析了208名病人的情况，他们都有一定的心痛和心律不齐的症状，在开始接受治疗时通过问卷报告了自己对病情的看法，其中约20%的人非常担忧病情会恶化，有的人甚至还害怕因此死亡，其他人就没有那么多担忧。
     
    后来的分析发现，那些有严重担忧情绪的人，血液中一些容易引起发炎的化学物质的含量要比其他人高。而早有研究显示，这些物质含量高会加重心脏病风险。
     
    领导研究的安德鲁·斯特普托教授解释说，担忧和害怕不仅是心理问题，这些情绪还会引起一些 生理反应，从而对病情造成实实在在的影响。不过研究人员也表示，本次研究还只是观察到这种现象，对于具体的深层原因以及调节心情是否能有效改善病情，还需 要进一步研究。（来源：新华网 黄堃）
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