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Small Nucleolar RNAs U32a, U33, and U35a Are Critical Mediators of Metabolic Stress

众星罗秋旻添加于 2011-7-30 10:53 | 1062 次阅读 | 0 个评论

作者
Michel CI, Holley CL, Scruggs BS, Sidhu R, Brookheart RT, Listenberger LL, Behlke MA, Ory DS, Schaffer JE
摘要
Lipotoxicity is a metabolic stress response implicated in the pathogenesis of diabetes complications and has been shown to involve lipid-induced oxidative stress. To elucidate the molecular mechanisms of lipotoxicity, we used retroviral promoter trap mutagenesis to isolate a cell line that is resistant to lipotoxic and oxidative stress. We show that loss of three box C/D small nucleolar RNAs (snoRNAs) encoded in the ribosomal protein L13a (rpL13a) locus is sufficient to confer resistance to lipotoxic and oxidative stress in vitro and prevents the propagation of oxidative stress in vivo. Our results provide evidence for a previously unappreciated, non-canonical role for box C/D snoRNAs as regulators of metabolic stress response pathways in mammalian cells.
详细资料
- 文献种类:期刊
- 期刊名称: Cell Metabolism
- 期刊缩写: Cell Metab
- 期卷页: 2011年第14卷第1期 33-44页
- 地址: Diabetic Cardiovascular Disease Center and Department of Medicine, Washington University, St. Louis, MO 63110, USA
- ISBN: 1550-4131
- 备注:PMID:21723502
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附件
Small Nucleolar RNAs U32a, U33, and U35a Are Critical Mediators of Metabolic Str
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