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Tumour necrosis factor and cancer

阿平添加于 2009-5-25 03:46 | 1220 次阅读 | 0 个评论

作者
Balkwill F
摘要
Tumour necrosis factor (TNF) is a major inflammatory cytokine that was first identified for its ability to induce rapid haemorrhagic necrosis of experimental cancers. When efforts to harness this anti-tumour activity in cancer treatments were underway, a paradoxical tumour-promoting role of TNF became apparent. Now that links between inflammation and cancer are appreciated, is TNF a target or a therapeutic in malignant disease -- or both?
详细资料
- 关键词: Animals; Clinical Trials as Topic; Cytotoxicity, Immunologic; DNA Damage; Endotoxins/toxicity; Humans; Inflammation/etiology; Neoplasms/drug therapy/*etiology; Receptors, Tumor Necrosis Factor/physiology; Recombinant Proteins/therapeutic use; Tumor Necrosis Factor-alpha/antagonists & inhibitors/*physiology/therapeutic use
- 文献种类:期刊
- 期刊名称: Nature Reviews. Cancer
- 期刊缩写: Nat Rev Cancer
- 期卷页: 2009年第9卷第5期 361-371页
- 地址: Centre for Cancer and Inflammation, Institute of Cancer, Barts, UK. Frances.balkwill@cancer.org.uk
- ISBN: 1474-1768
- 备注:PMID:19343034
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