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Evaluation of adhesion molecules CD64, CD11b and CD62L in neutrophils and monocytes of peripheral blood for early diagnosis of neonatal infection

xuechangbao 添加于 2011-9-1 15:37 | 1704 次阅读 | 0 个评论

作者
Genel F, Atlihan F, Gulez N, Kazanci E, Vergin C, Tumay Terek D, Cengel Yurdun O
摘要
BACKGROUND: This study was undertaken to assess the value of neutrophils CD11b, CD64, and CD62L for the early diagnosis of neonatal infection. METHODS: Eighty-four neonates who were followed up for a suspected neonatal infection were included in this study. They were assigned into an infection group (n=49) and a non-infection group (n=35). Healthy neonates served as controls (n=35). A full sepsis screening was performed and neutrophil and monocyte expressions of CD11b, CD64 and CD62L were determined by flow cytometry. RESULTS: The expressions of CD64 and CD11b were significantly enhanced in the infection group compared to the non-infective group and the controls. CONCLUSIONS: CD64 expression on neutrophils and monocytes is a useful diagnostic marker for the early diagnosis of neonatal infection. Combination of CD64, CD11b and C reactive protein further enhances the sensitivity of the expression and its negative predictive value.
详细资料
- 文献种类:期刊
- 期刊名称: World Journal of Pediatrics : WJP
- 期刊缩写: World J Pediatr
- 期卷页: 2011年
- 地址: Department of Pediatrics, Dr Behcet Uz Children's Hospital, Alsancak, Izmir, Turkey, ferahgen@yahoo.com
- ISBN: 1867-0687
- 备注:PMID:21874613
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附件
Evaluation of adhesion molecules CD64, CD11b and CD62L in neutrophils and monocy