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Application of the solvation parameter model in method development for analysis of residual solvents in pharmaceuticals

pharmacy 添加于 2009-8-28 17:51 | 1972 次阅读 | 0 个评论

作者
LIU Y, HU C
摘要
The solvation parameter model was applied in the development of a method for the analysis of residual solvents in pharmaceuticals. The interactions between organic solvents and six different stationary phases were studied using gas chromatography. The retention times of the organic solvents on these columns could be predicted under isothermal or temperature-programmed conditions using the established solvation parameter models. The predicted retention times helped in column selection and in optimizing chromatographic conditions during method development, and will form the basis for the development of a computer-aided method.
详细资料
- 文献种类:期刊
- 期刊名称: Journal of Chromatography A
- 期刊缩写: Journal of Chromatography A
- 期卷页: 2009年第1216卷第1期 86-91页
- ISBN: 0021-9673
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