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Clinical xenotransplantation: the next medical revolution?

唐唐添加于 2011-10-27 06:32 | 1673 次阅读 | 0 个评论

作者
Ekser B, Ezzelarab M, Hara H, van der Windt DJ, Wijkstrom M, Bottino R, Trucco M, Cooper DKC
摘要
The shortage of organs and cells from deceased individuals continues to restrict allotransplantation. Pigs could provide an alternative source of tissue and cells but the immunological challenges and other barriers associated with xenotransplantation need to be overcome. Transplantation of organs from genetically modified pigs into non-human primates is now not substantially limited by hyperacute, acute antibody-mediated, or cellular rejection, but other issues have become more prominent, such as development of thrombotic microangiopathy in the graft or systemic consumptive coagulopathy in the recipient. To address these problems, pigs that express one or more human thromboregulatory or anti-inflammatory genes are being developed. The results of preclinical transplantation of pig cells鈥攅g, islets, neuronal cells, hepatocytes, or corneas鈥攁re much more encouraging than they are for organ transplantation, with survival times greater than 1 year in all cases. Risk of transfer of an infectious microorganism to the recipient is small.
详细资料
- 文献种类:期刊
- 期刊名称: The Lancet
- 期刊缩写: The Lancet
- 期卷页: 2011年
- ISBN: 0140-6736
所属群组

医学综合
相关链接 DOI URL