Progesterone prevents depression-like behavior in a model of Parkinson's disease induced by 6-hydroxydopamine in male rats
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附 件Progesterone prevents depression-like behavior in a model of Parkinson's disease induced by 6-hydroxydopamine in male rats
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6-OHDA帕金森模型动物的抑郁行为表现
6-OHDA单侧损毁黑质纹状体系统。
麻醉：水合氯醛 400mg/kg i.p.
6-OHDA:2μg/μL-saline-0.1% ascorbic acid.
6-OHDA注射前30-40分钟，动物腹腔注射desipramine (地昔帕明）25mg/kg. 抑制去甲基肾上腺素能神经元吸收6-OHDA. 有助于选择性损毁。
动物：SD大鼠 60-120 days ,280-340g
分组：随机分组，包括正常无损伤动物组，生理盐水注射组和6-OHDA组，阳性药组……
行为学检测：
6-OHDA注射2星期后
安非他命诱导的同侧旋转实验： |
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