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Comparing antibody and small-molecule therapies for cancer

jiekel 添加于 2009-5-25 05:32 | 1751 次阅读 | 0 个评论

作者
Imai K, Takaoka A
摘要
The 'magic bullet' concept of specifically targeting cancer cells at the same time as sparing normal tissues is now proven, as several monoclonal antibodies and targeted small-molecule compounds have been approved for cancer treatment. Both antibodies and small-molecule compounds are therefore promising tools for target-protein-based cancer therapy. We discuss and compare the distinctive properties of these two therapeutic strategies so as to provide a better view for the development of new drugs and the future direction of cancer therapy.
详细资料
- 关键词: Antibodies, Monoclonal/*therapeutic use; Antineoplastic Agents/*therapeutic use; Drugs, Investigational/*therapeutic use; Humans; Neoplasms/*drug therapy/metabolism
- 文献种类:期刊
- 期刊名称: Nature Reviews. Cancer
- 期刊缩写: Nat Rev Cancer
- 期卷页: 2006年第6卷第9期 714-727页
- 地址: Sapporo Medical University, South 1, West 17, Chuo-ku, Sapporo, 060-8556, Japan. imai@sapmed.ac.jp
- ISBN: 1474-175X
- 备注:PMID:16929325
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