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[Vascular endothelial growth factor]

super1129 添加于 2012-2-23 17:31 | 1009 次阅读 | 0 个评论

作者
Kaiser R, Dubovy P, Haninec P
摘要
VEGF, vascular endothelial growth factor, is a substance firstly described in 1983 as a tumor-secreted protein which causes the development of ascitic fluid in case of abdominal tumors. Its influence on angiogenesis was ascertained by many studies. The strongest stimulus for its production is hypoxia, which leads to higher secretion of VEGF and new angiogenesis of so affected tissue. The neurogenic effect was firstly mentioned in 1999. Its protective and proliferative influence both on CNS and peripheral nerves is now widely accepted. It was demonstrated that VEGF has more wide ranging effect than previously thought.
详细资料
- 关键词: Humans; Neovascularization, Physiologic/physiology; Nervous System Physiological Phenomena; Signal Transduction; Vascular Endothelial Growth Factor A/pharmacology/*physiology/therapeutic use
- 文献种类:期刊
- 期刊名称: Ceskoslovenska Fysiologie / Ustredni Ustav Biologicky
- 期刊缩写: Cesk Fysiol
- 期卷页: 2011年第60卷第2期 48-51页
- 地址: Univerzita Karlova v Praze, 3. lekarska fakulta a FN Kralovske Vinohrady, Neurochirurgicka klinika, Praha. kaiser@fnkv.cz
- ISBN: 1210-6313
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