The statistical uncertainty in measuring the primordial density perturbations on a given comoving scale is dictated by the number of independent regions of that scale that are accessible to an observer. This number varies with cosmic time and diminishes per Hubble volume in the distant past or future of the standard cosmological model. We show that the best constraints on the initial power spectrum of linear density perturbations are accessible (e.g. through 21-cm intensity mapping) at redshifts z~10-50, and that the ability to constrain the cosmological initial conditions will deteriorate quickly in our cosmic future.
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