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A fatal clomipramine intoxication case of a chronic alcoholic patient: Application of postmortem hair analysis method of clomipramine and ethyl glucuronide using LC/APCI/MS

jiangfyh 添加于 2009-9-10 14:09 | 1663 次阅读 | 0 个评论

作者
KLYS M, SCISLOWSKI M, ROJEK S, KOLODZIEJ J
摘要
Toxicological investigations of postmortem specimens of a 26-year-old man were performed with the use of LC/ APCI/MS. They revealed in the blood of the deceased clomipramine (9.49 μg/g) and its main metabolite norclomipramine (1.10 μg/g) at concentrations explaining the fatal outcome. The presence of these xenobiotics in a 12-cm-long strand of hair ( clomipramine, 7.60 ng/mg in I segment; 4.19 ng/mg in II segment; 1.86 ng/mg in III segment; norclomipramine, 5.71 ng/mg in I segment; 9.71 ng/mg in II segment; 4.13 ng/mg in III segment) confirmed the fact obtained from the medical history that the deceased had been receiving clomipramine as an antidepressant for 1 year prior to his death. The analysis demonstrated ethanol in autopsy blood (2.5 mg/ml) and urine (3.2 mg/ml); ethyl glucuronide as a marker of chronic alcohol abuse was detected in the deceased's hair (0.44 ng/mg in I segment; 0.07 ng/mg in II segment; n.d. in III segment). These findings may suggest the contribution of alcohol in the mechanism of drug–ethanol interaction, which in consequence might have affected the biotransformation of clomipramine in the final period of his life and evoked the ultimate toxic effect.
详细资料
- 文献种类:期刊
- 期刊名称: Legal Medicine
- 期刊缩写: Legal Medicine
- 期卷页: 2005年第7卷第5期 319-325页
- ISBN: 1344-6223
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