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New insights into procathepsin D in pathological and physiological conditions

tianniao 添加于 2012-5-8 07:08 | 1094 次阅读 | 0 个评论

作者
Saraswat-Ohri S, Vetvicka V
摘要
Procathepsin D is a major glycoprotein that is secreted from numerous types of cancer cells including breast, lung and prostrate carcinomas. It affects multiple stages of tumorigenesis that include proliferation, invasion, metastasis and apoptosis. Previous studies showed that the mitogenic effect of procathepsin D on cancer cells was mediated through its propeptide or activation peptide. Recent studies have also implicated the possible use of procathepsin D/activation peptide as a marker of cancer progression. Considering the broad range of functions of procathepsin D, the present review summarizes the three major potentials of procathepsin D-cancer progression, tumor marker and wound healing.
详细资料
- 文献种类:期刊
- 期刊名称: North American Journal of Medical Sciences
- 期刊缩写: N Am J Med Sci
- 期卷页: 2011年第3卷第5期 222-226页
- 地址: Kentucky Spinal Cord Injury Centre, Department of Neurological Surgery, Louisville, KY 40202, USA
- ISBN: 1947-2714
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