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Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization

hxt_hz 添加于 2012-7-2 10:47 | 1295 次阅读 | 0 个评论

作者
Damania D, Roy HK, Subramanian H, Weinberg DS, Rex DK, Goldberg MJ, Muldoon J, Cherkezyan L, Zhu Y, Bianchi LK, Shah D, Pradhan P, Borkar M, Lynch H, Backman V
摘要
Developing a minimally invasive and cost-effective prescreening strategy for colon cancer is critical because of the impossibility of conducting colonoscopy on the entire at-risk population. The concept of field carcinogenesis, in which normal-appearing tissue away from a tumor has molecular and, consequently, nano-architectural abnormalities, offers one attractive approach to identify high-risk patients. In this study, we investigated whether the novel imaging technique partial wave spectroscopic (PWS) microscopy could risk-stratify patients harboring precancerous lesions of the colon, using an optically measured biomarker (L(d)) obtained from microscopically normal but nanoscopically altered cells. Rectal epithelial cells were examined from 146 patients, including 72 control patients, 14 patients with diminutive adenomas, 20 patients with nondiminutive/nonadvanced adenomas, 15 patients with advanced adenomas/high-grade dysplasia, 12 patients with genetic mutation leading to Lynch syndrome, and 13 patients with cancer. We found that the L(d) obtained from rectal colonocytes was well correlated with colon tumorigenicity in our patient cohort and in an independent validation set of 39 additional patients. Therefore, our findings suggest that PWS-measured L(d) is an accurate marker of field carcinogenesis. This approach provides a potential prescreening strategy for risk stratification before colonoscopy. Cancer Res; 72(11); 2720-7. (c)2012 AACR.
详细资料
- 文献种类:期刊
- 期刊名称: Cancer Research
- 期刊缩写: Cancer Res
- 期卷页: 2012年第72卷第11期 2720-2727页
- 地址: Authors' Affiliations: Biomedical Engineering Department, Northwestern University; Department of Internal Medicine, NorthShore University HealthSystem, Evanston, Illinois; Fox Chase Cancer Center, Philadelphia, Pennsylvania;Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Bloomington, Indiana; and Creighton University Medical Center-Saint Joseph Hospital, Omaha, Nebraska
- ISBN: 0008-5472
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