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Role of ErbB4 in breast cancer

icecream 添加于 2012-10-26 22:05 | 1086 次阅读 | 0 个评论

作者
Sundvall M, Iljin K, Kilpinen S, Sara H, Kallioniemi O-P, Elenius K
摘要
Members of the ErbB subfamily of receptor tyrosine kinases are important regulators of normal mammary gland physiology, and aberrations in their signaling have been associated with breast tumorigenesis. Therapeutics targeting epidermal growth factor receptor (EGFR = ErbB1) or ErbB2 in breast cancer have been approved for clinical use. In contrast, relatively little is known about the biological significance of ErbB4 signaling in breast cancer. This review focuses on recent advances in our understanding about the role of ErbB4 in breast carcinogenesis, as well as in the potential clinical relevance of ErbB4 in breast cancer prognostics and therapy.
详细资料
- 关键词: Alternative Splicing; Breast Neoplasms/drug therapy/genetics/*metabolism/pathology; Drug Delivery Systems; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Neuregulins/metabolism; Prognosis; Receptor, Epidermal Growth Factor/antagonists & inhibitors/genetics/*metabolism; Signal Transduction; Tumor Markers, Biological/genetics/*metabolism
- 文献种类:期刊
- 期刊名称: Journal of Mammary Gland Biology and Neoplasia
- 期刊缩写: J Mammary Gland Biol Neoplasia
- 期卷页: 2008年第13卷第2期 259-268页
- 地址: Department of Medical Biochemistry and Molecular Biology, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland
- ISBN: 1083-3021
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