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EGF-ERBB signalling: towards the systems level

icecream 添加于 2012-10-26 22:11 | 1094 次阅读 | 0 个评论

作者
Citri A, Yarden Y
摘要
Signalling through the ERBB/HER receptors is intricately involved in human cancer and already serves as a target for several cancer drugs. Because of its inherent complexity, it is useful to envision ERBB signalling as a bow-tie-configured, evolvable network, which shares modularity, redundancy and control circuits with robust biological and engineered systems. Because network fragility is an inevitable trade-off of robustness, systems-level understanding is expected to generate therapeutic opportunities to intercept aberrant network activation.
详细资料
- 关键词: Animals; Endocytosis/physiology; Epidermal Growth Factor/*metabolism; Feedback, Physiological; Humans; Ligands; Models, Molecular; Oncogene Proteins v-erbB/genetics/*metabolism; Phosphatidylinositol 3-Kinases/metabolism; Protein Conformation; Receptor, Epidermal Growth Factor/chemistry/genetics/metabolism; Signal Transduction/*physiology
- 文献种类:期刊
- 期刊名称: Nature Reviews. Molecular Cell Biology
- 期刊缩写: Nat Rev Mol Cell Biol
- 期卷页: 2006年第7卷第7期 505-516页
- 地址: Department of Biological Regulation, the Weizmann Institute of Science, 1 Hertzl Street, Rehovot 76100, Israel
- ISBN: 1471-0072
相关链接 DOI URL