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Cross-antigenicity among EV71 strains from different genogroups isolated in Yamagata, Japan, between 1990 and 2007

pipi302 添加于 2009-9-24 20:18 | 2334 次阅读 | 0 个评论

作者
Mizuta K, Aoki Y, Suto A, Ootani K, Katsushima N, Itagaki T, Ohmi A, Okamoto M, Nishimura H, Matsuzaki Y, Hongo S, Sugawara K, Shimizu H, Ahiko T
摘要
We isolated and identified six subgenogroups (B2, B4, B5, C1, C2, and C4) of enterovirus 71 (EV71) between 1990 and 2007 in Yamagata, Japan. We measured neutralizing antibody (NT Ab) titers against those subgenogroup strains and the BrCr reference strain for antigenic analysis. Serological analysis of 83 residents in Yamagata in 2004 showed that differences in the NT Ab titer of each individual against the different subgenogroups were mostly within 4-fold. Furthermore, sera from guinea pigs, immunized with the B2 and C1 strains indicated cross-antigenicity among the seven different subgenogroups. In conclusion, our results showed that cross-antigenicity exists among EV71 strains from different subgenogroups circulating in the community through genomic evolution. Our results also suggest that eliciting neutralizing antibodies against one genotype is likely to confer cross-neutralization against other genotypes.
详细资料
- 关键词: Animals; Antibodies, Viral/blood; Enterovirus A, Human/classification/genetics/*immunology/isolation & purification; Female; Genotype; Guinea Pigs; Japan; Neutralization Tests; Phylogeny; Time Factors
- 文献种类:期刊
- 期刊名称: Vaccine
- 期刊缩写: Vaccine
- 期卷页: 2009年第27卷第24期 3153-3158页
- 地址: Department of Microbiology, Yamagata Prefectural Institute of Public Health, Tokamachi 1-6-6, Yamagata, 990-0031, Japan. mizutak@pref.yamagata.jp
- ISBN: 0264-410X
- 备注:PMID:19446185
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