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有读书笔记有附件Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human

聚焦生物 添加于 2012-12-26 21:56 | 2910 次阅读 | 0 个评论

  •  作 者

    Wu J, Bostrom P, Sparks LM, Ye L, Choi JH, Giang A-H, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerback S, Schrauwen P, Spiegelman BM

  •  摘 要

    Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat: classical brown fat derived from a myf-5 cellular lineage and UCP1-positive cells that emerge in white fat from a non-myf-5 lineage. Here, we report the isolation of \"beige\" cells from murine white fat depots. Beige cells resemble white fat cells in having extremely low basal expression of UCP1, but, like classical brown fat, they respond to cyclic AMP stimulation with high UCP1 expression and respiration rates. Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin. Finally, we provide evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes. These data provide a foundation for studying this mammalian cell type with therapeutic potential. PAPERCLIP:

  •  详细资料

    • 关键词: Adipocytes/*classification/metabolism; Adipocytes, White/metabolism; Adipose Tissue, Brown/metabolism; Animals; Cell Separation; Gene Expression Profiling; Humans; Ion Channels/metabolism; Mice; Mitochondrial Proteins/metabolism
    • 文献种类:期刊
    • 期刊名称: Cell
    • 期刊缩写: Cell
    • 期卷页: 2012年  第150卷 第2期 366-376页
    • 地址: Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA
    • ISBN: 0092-8674

  • 相关链接 DOI URL 

  •  附 件

    PDF附件Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human 

  •  聚焦生物 的文献笔记  订阅

    Dana-Farber癌症研究所的科学家从成人体内成功分离出一种新型的燃烧能量的脂肪细胞，这一新型脂肪细胞可能是潜在的治疗肥胖的靶细胞。

    这一新发现的细胞称为“米色脂肪”，形状如豌豆大小，散落在在成人体内脊柱以及锁骨附近的皮肤下。根据研究人员Dana-Farber博士表示：这 一类型的脂肪的特点时候可以燃烧掉卡路里，而不是将它们存储起来。在传统意义上，“白色脂肪”细胞主要负责存储卡路里，因此米色脂肪细胞可能是治疗肥胖症 和糖尿病的新作用靶细胞。

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