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Rapid evolution of mammalian X-linked testis microRNAs

liufzhq 添加于 2013-1-22 11:19 | 1981 次阅读 | 0 个评论

作者
Guo X, Su B, Zhou Z, Sha J
摘要
Background MicroRNAs (miRNAs), which are small, non-coding RNAs approximately 21-nucleotides in length, have become a major focus of research in molecular biology. Mammalian miRNAs are proposed to regulate approximately 30% of all protein-coding genes. Previous studies have focused on highly conserved miRNAs, but nonconserved miRNAs represent a potentially important source of novel functionalities during evolution. Results An analysis of the chromosome distribution of miRNAs showed higher densities of miRNAs on the X chromosome compared to the average densities on autosomes in all eight mammalian species analyzed. The distribution pattern did not, however, apply well to species beyond mammals. In addition, by comparing orthologous human and mouse miRNAs, we found that X-linked miRNAs had higher substitution rates than autosomal miRNAs. Since the highest proportion of X-linked miRNAs were found in mouse testis, we tested the hypothesis that testis miRNAs are evolving faster on the X chromosome than on autosomes. Mature X-linked testis miRNAs had an average substitution rate between mouse and human that was almost 25-fold higher than mature testis miRNAs on autosomes. In contrast, for mature miRNAs with precursors not expressed in testis, no significant difference in the substitution rate between the X chromosome and autosomes was found. Among mammals, the rapid evolution of X-linked testis miRNAs was also observed in rodents and primates. Conclusion The rapid evolution of X-linked testis miRNAs implies possible important male reproductive functions and may contribute to speciation in mammals.
详细资料
- 文献种类:期刊
- 期刊名称: BMC Genomics
- 期刊缩写: BMC Genomics
- 期卷页: 2009年第10卷第1期 97页
- ISBN: 1471-2164
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In mammals，the densities of miRNAs in X chromosome are higher than autosomes. X-linked miRNAs had higher substitution rates than autosomal miRNAs. And the conserved targets of the X-linked testes miRNAS are enriched in the process involved in cell cycle.

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