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Gene-expression-based prognostic assays for breast cancer

flysui 添加于 2013-2-16 09:13 | 1165 次阅读 | 0 个评论

作者
Kim C, Paik S
摘要
Several gene-expression-based reference laboratory tests are now available for prognostication of patients diagnosed with breast cancer. For clinical oncologists, it is important to understand the clinical contexts for which these assays were developed in order to use them properly. This Review is aimed at providing a conceptual and technical overview of the steps involved in the development of gene-expression profiling-based prognostic assays. MammaPrint and Oncotype DX, two widely utilized assays, are compared with respect to differences in the clinical contexts for their development, technologies used, and clinical utilities with the aim of providing a guide to clinical oncologists for utilization of these assays.
详细资料
- 关键词: Biological Assay; Breast Neoplasms/*diagnosis/*genetics; Female; Gene Expression; Gene Expression Profiling/methods; Humans; Microarray Analysis; Prognosis
- 文献种类:期刊
- 期刊名称: Nature Reviews. Clinical Oncology
- 期刊缩写: Nat Rev Clin Oncol
- 期卷页: 2010年第7卷第6期 340-347页
- 地址: Division of Pathology, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212, USA
- ISBN: 1759-4774
相关链接 DOI URL