新科学想法 › 文献管理 › 浏览文献

Circulating microRNAs as potential new biomarkers for prostate cancer

pandon2002 添加于 2013-5-14 00:12 | 1294 次阅读 | 0 个评论

作者
Sita-Lumsden A, Dart DA, Waxman J, Bevan CL
摘要
Since they were first described in the 1990s, circulating microRNAs (miRNAs) have provided an active and rapidly evolving area of current research that has the potential to transform cancer diagnostics and therapeutics. In particular, miRNAs could provide potential new biomarkers for prostate cancer, the most common cause of cancer in UK men. Current diagnostic tests for prostate cancer have low specificity and poor sensitivity. Further, although many prostate cancers are so slow growing as not to pose a major risk to health, there is currently no test to distinguish between these and cancers that will become aggressive and life threatening. Circulating miRNAs are highly stable and are both detectable and quantifiable in a range of accessible bio fluids, thus have the potential to be useful diagnostic, prognostic and predictive biomarkers. This review aims to summarise the current understanding of circulating miRNAs in prostate cancer patients and their potential role as biomarkers.British Journal of Cancer advance online publication, 30 April 2013; doi:10.1038/bjc.2013.192 www.bjcancer.com.
详细资料
- 文献种类:期刊
- 期刊名称: British Journal of Cancer
- 期刊缩写: Br J Cancer
- 期卷页: 2013年
- 地址: Androgen Signalling Laboratory, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK
- ISBN: 0007-0920
相关链接 DOI URL