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Functional Role of MicroRNAs in Prostate Cancer and Therapeutic Opportunities

pandon2002 添加于 2013-5-14 00:13 | 1246 次阅读 | 0 个评论

作者
Maugeri-Sacca M, Coppola V, De Maria R, Bonci D
摘要
Prostate cancer is one of the most common causes of cancer-related death. The management of prostate cancer patients has become increasingly complex, consequently calling on the need for identifying and validating prognostic and predictive biomarkers. Growing evidence indicates that microRNAs play a crucial role in the pathobiology of neoplastic diseases. The deregulation of the cellular \"miRNome\" in prostate cancer has been connected with multiple tumor-promoting activities such as aberrant activation of growth signals, anti-apoptotic effects, prometastatic mechanisms, alteration of the androgen receptor pathway, and regulation of the cancer stem cell phenotype. With the elucidation of molecular mechanisms controlled by microRNAs, investigations have been conducted in an attempt to exploit these molecules in the clinical setting. Moreover, the multifaceted biological activity of microRNAs makes them an attractive candidate as anticancer agents. This review summarizes the current knowledge on microRNA deregulation in prostate cancer, and the rationale underlying their exploitation as cancer biomarkers and therapeutics.
详细资料
- 文献种类:期刊
- 期刊名称: Critical Reviews in Oncogenesis
- 期刊缩写: Crit Rev Oncog
- 期卷页: 2013年第18卷第4期 303-316页
- 地址: Regina Elena National Cancer Institute, Rome, Italy
- ISBN: 0893-9675
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