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Circulating MicroRNAs as Biomarkers of Prostate Cancer: The State of Play

pandon2002 添加于 2013-5-14 00:16 | 1229 次阅读 | 0 个评论

作者
Sapre N, Selth LA
摘要
MicroRNAs are key regulators of gene expression and play critical roles in both normal physiology and pathology. Recent research has demonstrated that these molecules are present in body fluids, such as serum, plasma, and urine, and can be readily measured using a variety of techniques. More importantly, emerging evidence suggests that circulating or urine miRNAs are useful indicators of disease. Here, we consider the potential utility of such miRNAs as noninvasive biomarkers of prostate cancer, a disease that would benefit substantially from novel diagnostic and prognostic tools. The studies aimed at identifying diagnostic, prognostic, and/or predictive miRNAs for prostate cancer are summarised and reviewed. Finally, practical considerations that will influence the translation of this recent research into clinical implementation are discussed.
详细资料
- 文献种类:期刊
- 期刊名称: Prostate Cancer
- 期刊缩写: Prostate Cancer
- 期卷页: 2013年第2013卷 539680页
- 地址: Department of Surgery, Royal Melbourne Hospital, The University of Melbourne, Level 5 Clinical Sciences Building, Parkville, Melbourne, VIC 3050, Australia
- ISBN: 2090-312X
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