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Mitochondrial dysfunction in glaucoma: understanding genetic influences

hxt_hz 添加于 2013-9-29 23:14 | 1453 次阅读 | 0 个评论

作者
Lascaratos G, Garway-Heath DF, Willoughby CE, Chau K-Y, Schapira AHV
摘要
Glaucoma is the leading cause of irreversible blindness worldwide. This review aims to provide a greater understanding of the complex genetic influences that may lead to mitochondrial dysfunction and increase susceptibility to retinal ganglion cell (RGC) loss in primary open angle glaucoma (POAG), and thus elucidate potentially important pathophysiological pathways amenable to therapeutic intervention. Emerging evidence from genome wide association and other genetic studies suggests that changes in the mitochondrial DNA (mtDNA) and in nuclear DNA genes that encode mitochondrial proteins may influence mitochondrial structure and function and, therefore, contribute to the pathogenesis of POAG. We propose that a variety of genes (OPA1, MFN1, MFN2, CYP1B1, PARL, SOD2, SRBD1, GST, NOS3, TNFa and TP53) may each confer a background susceptibility to POAG in different populations having one common link: mitochondrial dysfunction. The relationship between polymorphisms in these genes and increasing risk for POAG is presented and the limitations of the available current knowledge are discussed.
详细资料
- 关键词: Genes, Mitochondrial; Genetic Association Studies; Genetic Predisposition to Disease; Glaucoma, Open-Angle/congenital/*genetics/*physiopathology; Humans; Mitochondria/*pathology/*physiology; Mitochondrial Proteins/genetics
- 文献种类:期刊
- 期刊名称: Mitochondrion
- 期刊缩写: Mitochondrion
- 期卷页: 2012年第12卷第2期 202-212页
- 地址: NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, London EC1V 2PD, UK. glascaratos@gmail.com
- ISBN: 1567-7249
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