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Skeletal response to simulated weightlessness: a comparison of suspension techniques

heihei6 添加于 2015-10-15 14:24 | 1381 次阅读 | 0 个评论

作者
Wronski TJ, Morey-Holton ER
摘要
The skeletal response to simulated weightlessness was studied in rats subjected to two different methods of suspension. Skeletal unloading of the hind limbs for a two week period was achieved by use of either a back harness or tail traction. In comparison to pair-fed control rats, back-suspended rats failed to gain weight whereas tail-suspended rats exhibited normal weight gain. Quantitative bone histomorphometry revealed marked skeletal abnormalities in the proximal tibial metaphysis of back-suspended rats. Loss of trabecular bone mass in these animals was due to a combination of depressed longitudinal bone growth, decreased bone formation, and increased bone resorption. In contrast, the proximal tibia of tail-suspended rats was relatively normal by these histologic criteria. However, a significant reduction in trabecular bone volume occurred during 2 weeks of tail suspension, possibly due to a transient inhibition of bone formation during the early stages of skeletal unloading. Lack of weight gain in back-suspended rats may be indicative of a pronounced stress response during which corticosteroids adversely affected the skeleton. Maintenance of normal weight gain by tail-suspended rats provides evidence for the less traumatic nature of this method of suspension. Our findings indicate that tail suspension may be a more appropriate model for evaluating the effects of simulated weightlessness on skeletal homeostasis.
详细资料
- 关键词: Adipose Tissue/anatomy & histology; Animals; Bone Development; Bone Marrow/anatomy & histology; Bone and Bones/*anatomy & histology/cytology; Male; Methods; Rats; Rats, Inbred Strains; *Weightlessness
- 文献种类:期刊
- 期刊名称: Aviation, Space, and Environmental Medicine
- 期刊缩写: Aviat Space Environ Med
- 期卷页: 1987年第58卷第1期 63-68页
- ISBN: 0095-6562
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