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Synapse- and stimulus-specific local translation during long-term neuronal plasticity

auliuym 添加于 2009-12-3 15:12 | 1163 次阅读 | 0 个评论

作者
Wang DO, Kim SM, Zhao Y, Hwang H, Miura SK, Sossin WS, Martin KC
摘要
Long-term memory and synaptic plasticity require changes in gene expression and yet can occur in a synapse-specific manner. Messenger RNA localization and regulated translation at synapses are thus critical for establishing synapse specificity. Using live-cell microscopy of photoconvertible fluorescent protein translational reporters, we directly visualized local translation at synapses during long-term facilitation of Aplysia sensory-motor synapses. Translation of the reporter required multiple applications of serotonin, was spatially restricted to stimulated synapses, was transcript- and stimulus-specific, and occurred during long-term facilitation but not during long-term depression of sensory-motor synapses. Translational regulation only occurred in the presence of a chemical synapse and required calcium signaling in the postsynaptic motor neuron. Thus, highly regulated local translation occurs at synapses during long-term plasticity and requires trans-synaptic signals.
详细资料
- 文献种类:期刊
- 期刊名称: Science (New York, N.Y.)
- 期刊缩写: Science
- 期卷页: 2009年第324卷第5934期 1536-1540页
- 地址: Department of Psychiatry and Biobehavioral Sciences, University of California-Los Angeles (UCLA), BSRB 390B, 615 Charles E. Young Drive South, Los Angeles, CA 90095-1737, USA
- ISBN: 1095-9203
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