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Forcing cells to change lineages

th_chen 添加于 2009-12-15 12:45 | 2135 次阅读 | 0 个评论

作者
Graf T, Enver T
摘要
The ability to produce stem cells by induced pluripotency (iPS reprogramming) has rekindled an interest in earlier studies showing that transcription factors can directly convert specialized cells fromone lineage to another. Lineage reprogramming has become a powerful tool to study cell fate choice during differentiation, akin to inducing mutations for the discovery of gene functions. The lessons learnt provide a rubric for how cells may be manipulated for therapeutic purposes.
详细资料
- 文献种类:期刊
- 期刊名称: Nature
- 期刊缩写: Nature
- 期卷页: 2009年第462卷第7273期 587-594页
- ISBN: 0028-0836
标签

ips lineage reprogram regenerative medicine transcription factor
相关链接 DOI URL
附件
Forcing cells to change lineages Forcing cells to change lineages
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