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Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase

leeallanchina 添加于 2010-1-5 02:12 | 3641 次阅读 | 0 个评论

作者
Fay JR, Steele V, Crowell JA
摘要
Caloric restriction has long been recognized as an extremely effective cancer preventive. Current population demographics suggest that caloric excess and obesity will lead to increased cancer incidence, underscoring the need to elucidate the molecular mechanisms that couple dysregulated energy homeostasis to aberrant cell growth. The AMP-activated protein kinase (AMPK) is a critical monitor of cellular energy status, largely studied for its importance in metabolic regulation. AMPK also controls processes relevant to tumor development, including cell cycle progression, protein synthesis, cell growth, and survival. Several tumor suppressors impinge on AMPK signaling, and activation of the kinase inhibits tumor growth. However, AMPK can also promote cancer in some settings, necessitating a more complete understanding of the complexities of this signaling network. Because dysregulated energy balance is a nexus for multiple chronic diseases of aging, drugs that target these pathways may find broad utility in aging populations.
详细资料
- 文献种类:期刊
- 期刊名称: Cancer Prevention Research
- 期刊缩写: Cancer Prevention Research
- 期卷页: 2009年第2卷第4期 301-309页
- ISBN: 1940-6207
标签

AMPK • cancer prevention chemoprevention chronic diseases of aging metformin
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