Overcoming inhibition in the spindle checkpoint
weilijunhit 添加于 2010-1-24 14:28
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作 者
Vanoosthuyse V, Hardwick KG 摘 要
Spindle checkpoint silencing is a critical step during mitosis that initiates chromosome segregation, yet surprisingly little is known about its mechanism. Protein phosphatase I (PP1) was shown recently to be a key player in this process, and in this issue of Genes & Deverlopment, Akiyoshi and colleagues (pp. 2887-2899) identify budding yeast Fin1p as a kinetochore-localized regulator of PP1 activity toward checkpoint targets. Here we review recent mechanistic insights and propose a working model for spindle checkpoint silencing.-
详细资料
- 关键词: *Gene Expression Regulation, Fungal; Kinetochores/metabolism; Mitotic Spindle Apparatus/*metabolism; Models, Biological; Protein Phosphatase 1/metabolism; Signal Transduction; *Yeasts/enzymology/genetics
- 文献种类:期刊
- 期刊名称: Genes & Development
- 期刊缩写: Genes Dev
- 期卷页: 2009年 第23卷 第24期 2799-2805页
- 地址: Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom. vvanoost@staffmail.ed.ac.uk
- ISBN: 1549-5477
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